Abstract
Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor "hypoxia-inducible factor 1-alpha" (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.
MeSH terms
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Animals
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Cell Polarity
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Cell Proliferation
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Cytokines / physiology
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Disease Models, Animal
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / physiology*
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Interleukin-1 / physiology
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Mice
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Neovascularization, Physiologic
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Psoriasis / etiology*
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Psoriasis / immunology
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Th17 Cells / physiology
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Vascular Endothelial Growth Factor A / physiology
Substances
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Cytokines
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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Interleukin-1
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Vascular Endothelial Growth Factor A
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interleukin 36, human