Fatty acid binding protein 2 (FABP2) Ala54Thr gene polymorphism has been suggested to be associated with the increased risk of developing type 2 diabetes mellitus (T2DM), but some studies show the inconsistent result. The purpose of this meta-analysis is to assess the association between FABP2 Ala54Thr gene polymorphism variants and the T2DM. A total of 7095 subjects in 11 case-control studies were included in this meta-analysis. Under the allele model (T versus A), the pooled OR of Asian subgroup was 1.19 (95% CI = 1.06-1.32, P = 0.002). Under the recessive model (TT versus AA + AT), the pooled OR of Asian subgroup was 1.34 (95% CI = 1.05-1.71, P = 0.02). Under the dominant model (TT + AT versus AA), the pooled OR was 1.14 (95% CI = 1.03-1.27, P = 0.01) and when the analysis stratified by region, increased risks were identified among Asian (OR = 1.20, 95% CI = 1.05-1.38, P = 0.009). Under the codominant model (TT versus AA), no significant association was found. Under the codominant model (AT versus AA), the pooled OR was 1.14 (95% CI = 1.02-1.27, P = 0.02). It is indicated that the variant T allele carrier may increased the risk of T2DM and the risk is related to race.
Keywords: Diabetes mellitus; fatty acid-binding protein 2; meta-analysis; polymorphism.