The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports.
Keywords: carbamates; cleavage reactions; esters; protecting groups; solid-phase synthesis.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.