MgI2 -mediated chemoselective cleavage of protecting groups: an alternative to conventional deprotection methodologies

Chemistry. 2015 Jul 27;21(31):11014-6. doi: 10.1002/chem.201501799. Epub 2015 Jun 29.

Abstract

The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports.

Keywords: carbamates; cleavage reactions; esters; protecting groups; solid-phase synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / chemistry
  • Esterification
  • Esters / chemistry
  • Green Chemistry Technology
  • Iodides / chemical synthesis
  • Iodides / chemistry*
  • Magnesium Compounds / chemical synthesis
  • Magnesium Compounds / chemistry*
  • Solid-Phase Synthesis Techniques / methods*
  • Solvents

Substances

  • Amino Acids
  • Esters
  • Iodides
  • Magnesium Compounds
  • Solvents
  • magnesium iodide