Abstract
This communication presents the first Gd(III)-based T1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg(+). o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg(+). Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg(+). Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg(+) and could be useful for biomedical applications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Intravenous
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Animals
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Contrast Media / chemistry*
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Environmental Pollutants / administration & dosage
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Environmental Pollutants / analysis*
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Environmental Pollutants / pharmacokinetics
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Gadolinium / chemistry*
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Intestinal Mucosa / metabolism
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Intestines / chemistry
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Kidney / chemistry
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Kidney / metabolism
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Liver / chemistry
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Liver / metabolism
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Magnetic Resonance Imaging / methods*
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Methylmercury Compounds / administration & dosage
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Methylmercury Compounds / analysis*
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Methylmercury Compounds / pharmacokinetics
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Nude
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Neurotoxins / administration & dosage
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Neurotoxins / analysis*
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Neurotoxins / pharmacokinetics
Substances
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Contrast Media
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Environmental Pollutants
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Methylmercury Compounds
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Neurotoxins
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Gadolinium