A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells

Chem Commun (Camb). 2015 Aug 4;51(60):12024-7. doi: 10.1039/c5cc03432a.

Abstract

A short GC rich DNA derived from microbial origin interacts with tubulin/microtubules activates p53 over expression and induces apoptotic death of human breast cancer (MCF-7) cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Base Sequence
  • Cell Cycle / drug effects
  • Cell Line, Tumor
  • DNA / chemistry*
  • DNA / pharmacology*
  • Female
  • HeLa Cells
  • Humans
  • MCF-7 Cells
  • Microtubules / drug effects*
  • Microtubules / metabolism
  • Microtubules / pathology
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Tubulin / metabolism*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Antineoplastic Agents
  • Tubulin
  • Tumor Suppressor Protein p53
  • DNA