Placental and fetal cysteine dioxygenase gene expression in mouse gestation

J Rakoczy; S Lee; S J Weerasekera; D G Simmons; P A Dawson

doi:10.1016/j.placenta.2015.06.003

Placental and fetal cysteine dioxygenase gene expression in mouse gestation

Placenta. 2015 Aug;36(8):956-9. doi: 10.1016/j.placenta.2015.06.003. Epub 2015 Jun 19.

Authors

J Rakoczy¹, S Lee², S J Weerasekera², D G Simmons³, P A Dawson⁴

Affiliations

¹ Mater Research Institute, University of Queensland, Woolloongabba, Australia; School of Biomedical Sciences, University of Queensland, St. Lucia, Australia.
² Mater Research Institute, University of Queensland, Woolloongabba, Australia.
³ School of Biomedical Sciences, University of Queensland, St. Lucia, Australia.
⁴ Mater Research Institute, University of Queensland, Woolloongabba, Australia; School of Biomedical Sciences, University of Queensland, St. Lucia, Australia. Electronic address: paul.dawson@mater.uq.edu.au.

PMID: 26119969
DOI: 10.1016/j.placenta.2015.06.003

Abstract

Nutrient sulfate is important for fetal development. The fetus has a limited capacity to generate sulfate and relies on maternal sulfate supplied via the placenta. The gestational age when fetal sulfate generation begins is unknown but would require cysteine dioxygenase (CDO1) which mediates a major step of sulfate production from cysteine. We investigated the ontogeny of Cdo1 mRNA expression in mouse fetal and placental tissues, which showed increasing levels from embryonic day 10.5 and was localised to the decidua and several fetal tissues including nasal cavities and brain. These findings suggest a role for Cdo1 in sulfate generation from mid-gestation.

Keywords: Cysteine dioxygenase; Decidua; Fetus; Placenta; Pregnancy; Sulfate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism
Cysteine Dioxygenase / genetics*
Cysteine Dioxygenase / metabolism
Female
Fetus / metabolism*
Gene Expression*
Mice
Placenta / metabolism*
Pregnancy

Substances

Cysteine Dioxygenase