Hydroxychloroquine screening practice patterns within a large multispecialty ophthalmic practice

Am J Ophthalmol. 2015 Sep;160(3):561-568.e2. doi: 10.1016/j.ajo.2015.06.009. Epub 2015 Jun 24.

Abstract

Purpose: To determine provider compliance with hydroxychloroquine screening following the revised recommendations published in 2011 by the American Academy of Ophthalmology.

Design: Evaluation of adherence to a screening protocol.

Methods: Subjects were identified with hydroxychloroquine as a medication by electronic query at a large multispecialty ophthalmic practice. Patients were excluded if patients: (1) were screened by an outside physician; (2) lacked recorded height, weight, start date, or dosing; or (3) took hydroxychloroquine for malaria prophylaxis. Screening tests were stratified by ophthalmic subspecialty. Guidelines define proper screening as 1 subjective test-Humphrey visual field (HVF), and 1 objective test-spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence (FAF), or multifocal electroretinography (mfERG). Adherence to guidelines was determined by categorizing practices as: (1) "appropriate"-consistent with guidelines; (2) "underscreened"-insufficient testing; or (3) "inappropriate"-no testing.

Results: The study comprised 756 patients with a mean age of 56 years undergoing 1294 screening visits. Twenty-one patients received initial screenings outside the institution. Most common screening tests employed included SD OCT (56.6%), 10-2 HVF (55.0%), and Amsler grid (40.0%). Of the 735 initial screenings, 341 (46.4%) were appropriately screened, 204 (27.8%) underscreened, and 190 (25.9%) inappropriately screened. Of those who presented solely for screening (560), 307 (54.8%) were appropriately screened, 144 (25.7%) underscreened, and 109 (19.5%) inappropriately screened.

Conclusions: Of patients presenting for hydroxychloroquine screening, 54.8% of patients received appropriate evaluation, indicating lack of adherence to guidelines. Overall, SD OCT and 10-2 HVF were the preferred screening modalities, with FAF and mfERG less frequently ordered.

MeSH terms

  • Academies and Institutes / standards
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antirheumatic Agents / toxicity*
  • Child
  • Electroretinography
  • Female
  • Guideline Adherence / standards*
  • Humans
  • Hydroxychloroquine / toxicity*
  • Male
  • Mass Screening / standards
  • Middle Aged
  • Ophthalmology / organization & administration
  • Ophthalmology / standards
  • Practice Guidelines as Topic / standards
  • Practice Patterns, Physicians' / statistics & numerical data*
  • Retina / drug effects
  • Retinal Diseases / chemically induced*
  • Retinal Diseases / diagnosis*
  • Tomography, Optical Coherence
  • Visual Field Tests

Substances

  • Antirheumatic Agents
  • Hydroxychloroquine