NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

Sergei N Orlov; Svetlana V Koltsova; Leonid V Kapilevich; Svetlana V Gusakova; Nickolai O Dulin

doi:10.1016/j.gendis.2015.02.007

NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

Genes Dis. 2015 Jun;2(2):186-196. doi: 10.1016/j.gendis.2015.02.007.

Authors

Sergei N Orlov¹, Svetlana V Koltsova², Leonid V Kapilevich³, Svetlana V Gusakova⁴, Nickolai O Dulin⁵

Affiliations

¹ Faculty of Biology, M.V. Lomonosov Moscow State University, Russia ; Tomsk State University, Russia.
² Faculty of Biology, M.V. Lomonosov Moscow State University, Russia.
³ Tomsk State University, Russia ; Siberian State Medical University, Russia.
⁴ Siberian State Medical University, Russia.
⁵ University of Chicago Department of Medicine, USA.

Abstract

This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.

Keywords: NKCC cotransport; hypertension; intracellular chloride; myogenic tone; neuronal cell; smooth muscle.

Abstract

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