Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Molecules. 2015 Jun 23;20(6):11554-68. doi: 10.3390/molecules200611554.

Abstract

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.

Keywords: Trypanosoma cruzi; amastigotes; aminoalcohols; cytotoxicity; diamines; epimastigotes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / administration & dosage
  • Alcohols / chemistry
  • Animals
  • Chagas Disease / drug therapy*
  • Chagas Disease / parasitology
  • Chlorocebus aethiops
  • Diamines / administration & dosage*
  • Diamines / chemistry
  • Humans
  • Trypanocidal Agents / administration & dosage*
  • Trypanocidal Agents / chemistry
  • Trypanosoma cruzi / drug effects*
  • Trypanosoma cruzi / pathogenicity
  • Vero Cells

Substances

  • Alcohols
  • Diamines
  • Trypanocidal Agents