Modeling the finger instability in an expanding cell monolayer

Integr Biol (Camb). 2015 Oct;7(10):1218-27. doi: 10.1039/c5ib00092k. Epub 2015 Jun 22.

Abstract

Collective motion occurs in many biological processes, such as wound healing, tumor invasion and embryogenesis. Experiments of cell monolayer migration have revealed the spontaneous formation of finger-like instabilities, with leader cells at their tips. We present a particle-based model for collective cell migration, based on several elements that have been found experimentally to influence cellular movement. Inside the bulk we include velocity alignment interactions between neighboring cells. At the border contour of the layer we introduce the following additional forces: surface-elasticity restoring force, curvature-dependent positive feedback, and contractile acto-myosin cables. We find that the curvature-driven instability at the layer edge is necessary and sufficient for the formation of cellular fingers, which are in good agreement with experimental observations.

MeSH terms

  • Actomyosin / physiology
  • Animals
  • Biomechanical Phenomena
  • Cell Culture Techniques
  • Cell Movement / physiology*
  • Cell Proliferation
  • Cell Surface Extensions / physiology*
  • Computer Simulation
  • Elasticity
  • Embryonic Development / physiology
  • Humans
  • Models, Biological*
  • Neoplasm Invasiveness / physiopathology
  • Wound Healing / physiology

Substances

  • Actomyosin