Fibrosarcoma arising from gouty tophi: report of a unique case and review of literature

Int J Clin Exp Pathol. 2015 Apr 1;8(4):4227-32. eCollection 2015.

Abstract

Fibrosarcoma is a malignant mesenchymal tumor. To the author's best knowledge, no previous case of fibrosarcoma arising from gouty tophi has been reported. Here we reported the first case of fibrosarcoma arising from gouty tophi. A case of 58-year-old man was presented with a mass with ulcer and infection in the second joint of left middle finger for 2 months, with long standing gouty tophi. The tumor was biopsied and the biopsy showed complete excision of the tumor. With the pathological and immunohistochemical features considered, the diagnosis of fibrosarcoma associated with gouty tophi was made. The clinical findings, pathological characteristics and treatment were described.

Keywords: Fibrosarcoma; gout; gouty tophi; sarcoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics
  • Biopsy
  • Fibrosarcoma / chemistry
  • Fibrosarcoma / etiology*
  • Fibrosarcoma / genetics
  • Fibrosarcoma / pathology
  • Fibrosarcoma / surgery
  • Finger Joint / chemistry
  • Finger Joint / pathology*
  • Finger Joint / surgery
  • Gout / complications*
  • Gout / pathology
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Male
  • Middle Aged
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / etiology*
  • Soft Tissue Neoplasms / genetics
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / surgery

Substances

  • Biomarkers, Tumor