pH-Responsive H-Type PMAA2 -b-HTPBN-b-PMAA2 Four-Arm Star Block Copolymer Micelles for PTX Drug Release

Macromol Biosci. 2015 Oct;15(10):1411-22. doi: 10.1002/mabi.201500103. Epub 2015 Jun 11.

Abstract

pH-Responsive H-type poly(methylacrylic acid-block-four hydroxyl terminated poly(butadiene-acrylobitrile)-block-poly(methylacrylic acid (PMAA2 -b-HTPBN-b-PMAA2 ) block copolymers were synthesized via atom transfer radical polymerization and the follow-up hydrolysis, and characterized by (1) H NMR, FT-IR and SEC. The block copolymers could self-assemble into nanoscale spherical core-shell micelle aggregates in aqueous solution, and the physicochemical properties depended on the system composition and pH media, with pH phase transition at 5.7-6.1. The copolymer micelle aggregates exhibited pH-triggered drug release and cytotoxicity, and could potentially be used as drug targeting release carriers.

Keywords: biomaterials; drug delivery systems; micelles; self-assembly; stimuli-sensitive polymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Liberation*
  • Humans
  • Hydrogen-Ion Concentration
  • Mice
  • Micelles*
  • Microscopy, Electron, Transmission
  • Paclitaxel / pharmacology*
  • Phase Transition
  • Polymethacrylic Acids / chemical synthesis
  • Polymethacrylic Acids / chemistry*
  • Proton Magnetic Resonance Spectroscopy
  • Surface Tension

Substances

  • Micelles
  • PMAA2-b-HTPBN-b-PMAA2
  • Polymethacrylic Acids
  • polymethacrylic acid
  • Paclitaxel