Down Syndrome with Patent Ductus Venosus and Hepato-Biliary-Pancreatic Abnormalities

Indian J Pediatr. 2016 Jan;83(1):78-80. doi: 10.1007/s12098-015-1797-0. Epub 2015 Jun 23.

Abstract

The association between Down syndrome and congenital portosystemic shunts, most commonly caused by patent ductus venosus, remains relatively unknown. The authors present a girl with Down syndrome with patent ductus venosus, pancreaticobiliary maljunction and paucity of interlobular bile ducts, presenting with neonatal cholestasis and transient abnormal myeloproliferative disorder. To the best of authors' knowledge, no report of the concurrent presence of the above in Down syndrome has been published.

Keywords: Down syndrome; Neonatal cholestasis; Patent ductus venosus; Portosystemic shunt.

Publication types

  • Case Reports

MeSH terms

  • Biliary Tract* / abnormalities
  • Biliary Tract* / diagnostic imaging
  • Cholangiography / methods
  • Digestive System Abnormalities* / diagnosis
  • Digestive System Abnormalities* / surgery
  • Disease Management
  • Down Syndrome / complications*
  • Down Syndrome / diagnosis
  • Female
  • Humans
  • Infant, Newborn
  • Leukemoid Reaction / complications*
  • Leukemoid Reaction / diagnosis
  • Liver* / abnormalities
  • Liver* / diagnostic imaging
  • Liver* / pathology
  • Pancreas* / abnormalities
  • Pancreas* / diagnostic imaging
  • Portal Vein / abnormalities*
  • Portal Vein / physiopathology
  • Ultrasonography / methods
  • Vascular Malformations* / diagnosis
  • Vascular Malformations* / physiopathology

Supplementary concepts

  • Myeloproliferative Syndrome, Transient
  • Patent Ductus Venosus