NF-κB signaling in B-1 cell development

Ann N Y Acad Sci. 2015 Dec:1362:39-47. doi: 10.1111/nyas.12800. Epub 2015 Jun 11.

Abstract

NF-κB transcription factors play essential roles in hematopoiesis. In this review, we summarize the requirements of different components of the NF-κB pathway for B-1 cell development and maintenance. The B-1 cell developmental steps are also reviewed, with particular emphasis on stages where NF-κB signaling may be critical.

Keywords: B-1a cells; B-1b cells; IκB; IκBNS; LUBAC; NEMO.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / physiology*
  • Gene Knockout Techniques
  • Humans
  • NF-kappa B / physiology*
  • Signal Transduction / physiology*

Substances

  • NF-kappa B