NF-κB transcription factors play essential roles in hematopoiesis. In this review, we summarize the requirements of different components of the NF-κB pathway for B-1 cell development and maintenance. The B-1 cell developmental steps are also reviewed, with particular emphasis on stages where NF-κB signaling may be critical.
Keywords: B-1a cells; B-1b cells; IκB; IκBNS; LUBAC; NEMO.
© 2015 New York Academy of Sciences.