Abstract
Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH-induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity.
Keywords:
CYP2E1; hepatotoxicity mechanisms; isoniazid.
Copyright © 2015 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antitubercular Agents / pharmacokinetics
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Antitubercular Agents / toxicity*
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Apoptosis / drug effects
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Chemical and Drug Induced Liver Injury / enzymology
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Chemical and Drug Induced Liver Injury / etiology*
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Chemical and Drug Induced Liver Injury / pathology
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Cytochrome P-450 Enzyme System / metabolism
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Cytochrome P450 Family 2
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Humans
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Isoniazid / pharmacokinetics
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Isoniazid / toxicity*
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Mitochondria, Liver / drug effects
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Mitochondria, Liver / pathology
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Oxidative Stress / drug effects
Substances
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Antitubercular Agents
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Cytochrome P-450 Enzyme System
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CYP2F1 protein, human
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Cytochrome P450 Family 2
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Isoniazid