Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

Chem Commun (Camb). 2015 Jul 21;51(57):11519-22. doi: 10.1039/c5cc03711e.

Abstract

Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups (ZBGs), has been investigated as a carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be exploited to design new, effective and selective CAIs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbonic Anhydrase Inhibitors / chemistry*
  • Carbonic Anhydrase Inhibitors / pharmacology
  • Carbonic Anhydrases / chemistry
  • Carbonic Anhydrases / metabolism*
  • Catalytic Domain
  • Drug Design
  • Humans
  • Hydroxylamine / chemistry*
  • Hydroxylamine / pharmacology
  • Molecular Docking Simulation
  • Sulfonamides / chemistry*
  • Sulfonamides / pharmacology

Substances

  • Carbonic Anhydrase Inhibitors
  • Sulfonamides
  • Hydroxylamine
  • Carbonic Anhydrases