Abstract
Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups (ZBGs), has been investigated as a carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be exploited to design new, effective and selective CAIs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbonic Anhydrase Inhibitors / chemistry*
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Carbonic Anhydrase Inhibitors / pharmacology
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Carbonic Anhydrases / chemistry
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Carbonic Anhydrases / metabolism*
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Catalytic Domain
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Drug Design
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Humans
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Hydroxylamine / chemistry*
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Hydroxylamine / pharmacology
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Molecular Docking Simulation
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Sulfonamides / chemistry*
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Sulfonamides / pharmacology
Substances
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Carbonic Anhydrase Inhibitors
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Sulfonamides
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Hydroxylamine
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Carbonic Anhydrases