Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine

M A Kiselev; E V Zemlyanaya; O M Ipatova; A Yu Gruzinov; E V Ermakova; A V Zabelin; E I Zhabitskaya; O S Druzhilovskaya; V L Aksenov

doi:10.1016/j.jpba.2015.05.034

Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine

J Pharm Biomed Anal. 2015 Oct 10:114:288-91. doi: 10.1016/j.jpba.2015.05.034. Epub 2015 Jun 1.

Authors

M A Kiselev¹, E V Zemlyanaya², O M Ipatova³, A Yu Gruzinov⁴, E V Ermakova², A V Zabelin⁴, E I Zhabitskaya⁵, O S Druzhilovskaya³, V L Aksenov⁶

Affiliations

¹ Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia. Electronic address: kiselev@nf.jinr.ru.
² Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia.
³ V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
⁴ National Research Center «Kurchatov Institute», Moscow, Russia.
⁵ Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia; International University "Dubna", Dubna, Moscow Region 141980 Russia.
⁶ Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia; Petersburg Nuclear Physics Institute, NRC «Kurchatov Institute», Gatchina, Russia.

PMID: 26093243
DOI: 10.1016/j.jpba.2015.05.034

Abstract

Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2Å.

Keywords: Drug carriers; Synchrotron; Vesicles; X-ray scattering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers*
Drug Delivery Systems
Emulsions
Glycine max / chemistry*
Lipid Bilayers / chemistry
Micelles
Nanoparticles / chemistry*
Phosphatidylcholines / chemistry*
Scattering, Radiation
Solvents
X-Rays

Substances

Drug Carriers
Emulsions
Lipid Bilayers
Micelles
Phosphatidylcholines
Solvents