Pharmacokinetic Properties of a New Glutamic Acid Derivative Glutaron

Bull Exp Biol Med. 2015 Jun;159(2):229-31. doi: 10.1007/s10517-015-2929-2. Epub 2015 Jun 20.

Abstract

Inhomogenous distribution of glutaron in organs and tissues was found after intravenous and peroral administration: the agent demonstrated high affinity to organs with high degree of vascularization (lungs and heart) and elimination (kidney). Glutaron easily penetrates through the blood-brain barrier, which is consistent with its concentration in the adipose tissue.

MeSH terms

  • Adipose Tissue / metabolism*
  • Administration, Intravenous
  • Administration, Oral
  • Animals
  • Area Under Curve
  • Blood-Brain Barrier / metabolism*
  • Chromatography, Liquid
  • Glutamic Acid / administration & dosage
  • Glutamic Acid / analogs & derivatives*
  • Glutamic Acid / chemistry
  • Glutamic Acid / pharmacokinetics*
  • Male
  • Rats
  • Viscera / metabolism*

Substances

  • RGPU-135
  • Glutamic Acid