Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses

Janine Mühe; Fred Wang

doi:10.1128/JVI.01235-15

Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses

J Virol. 2015 Sep;89(17):9133-6. doi: 10.1128/JVI.01235-15. Epub 2015 Jun 17.

Authors

Janine Mühe¹, Fred Wang²

Affiliations

¹ Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, and Department of Molecular Biology & Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
² Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, and Department of Molecular Biology & Immunobiology, Harvard Medical School, Boston, Massachusetts, USA fwang@research.bwh.harvard.edu.

Abstract

Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.

MeSH terms

Amino Acid Sequence
Animals
B-Lymphocytes / immunology
B-Lymphocytes / virology
Base Sequence
Cercopithecidae / immunology
Cercopithecidae / virology*
Epstein-Barr Virus Nuclear Antigens / genetics
Herpesviridae Infections / pathology
Herpesviridae Infections / virology
Herpesvirus 4, Human / pathogenicity*
Host Specificity*
Humans
Lymphocryptovirus / pathogenicity*
Molecular Sequence Data
Monkey Diseases / virology*
Sequence Alignment
Sequence Analysis, DNA
Viral Proteins / genetics

Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses

Authors

Affiliations

Abstract

MeSH terms

Substances

Associated data

Grants and funding