Biomedical Applications of Magnetically Functionalized Organic/Inorganic Hybrid Nanofibers

Hwa-Jeong Lee; Sang Joon Lee; Saji Uthaman; Reju George Thomas; Hoon Hyun; Yong Yeon Jeong; Chong-Su Cho; In-Kyu Park

doi:10.3390/ijms160613661

Biomedical Applications of Magnetically Functionalized Organic/Inorganic Hybrid Nanofibers

Int J Mol Sci. 2015 Jun 15;16(6):13661-77. doi: 10.3390/ijms160613661.

Authors

Hwa-Jeong Lee¹, Sang Joon Lee², Saji Uthaman³, Reju George Thomas⁴, Hoon Hyun⁵, Yong Yeon Jeong⁶, Chong-Su Cho⁷, In-Kyu Park⁸

Affiliations

¹ Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea. hjl1510@gmail.com.
² Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea. kg2080@gmail.com.
³ Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea. sajiuthaman@gmail.com.
⁴ Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Korea. regeth@gmail.com.
⁵ Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea. hhyun@jnu.ac.kr.
⁶ Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Korea. yjeong@jnu.ac.kr.
⁷ Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea. chocs@snu.ac.kr.
⁸ Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea. pik96@chonnam.ac.kr.

Abstract

Nanofibers are one-dimensional nanomaterial in fiber form with diameter less than 1 µm and an aspect ratio (length/diameter) larger than 100:1. Among the different types of nanoparticle-loaded nanofiber systems, nanofibers loaded with magnetic nanoparticles have gained much attention from biomedical scientists due to a synergistic effect obtained from the unique properties of both the nanofibers and magnetic nanoparticles. These magnetic nanoparticle-encapsulated or -embedded nanofiber systems can be used not only for imaging purposes but also for therapy. In this review, we focused on recent advances in nanofibers loaded with magnetic nanoparticles, their biomedical applications, and future trends in the application of these nanofibers.

Keywords: Cancer therapy; electrospinning; magnetic nanoparticles; nanofibers; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / therapeutic use
Nanofibers / chemistry*
Nanofibers / therapeutic use
Neoplasms / therapy*
Polymers / chemistry

Substances

Magnetite Nanoparticles
Polymers