Prevalence and specificity of Baeyer-Villiger monooxygenases in fungi

Phytochemistry. 2015 Sep:117:144-153. doi: 10.1016/j.phytochem.2015.06.009. Epub 2015 Jun 12.

Abstract

Out of 107 fungal strains belonging to three phyla (Ascomycota, Basidiomycota and Zygomycota) and 46 genera, 86 exhibited Baeyer-Villiger monooxygenase (BVMO) activity against racemic bicyclo[3.2.0]heptenone. The strains were classified into three "profiles" based on regio- and enantioselectivity. Statistical analyses of our results, extended by literature data, showed that these profiles could be related to the taxonomic classification of the strains, and suggest that the BVMOs from the Zygomycota phylum may be different in their primary structures from established ones.

Keywords: Ascomycetes; Baeyer–Villiger monooxygenase; Basidiomycetes; Enantioselectivity; Fungi; Phylum; Regioselectivity; Screening; Zygomycetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota* / enzymology
  • Ascomycota* / genetics
  • Ascomycota* / metabolism
  • Basidiomycota* / enzymology
  • Basidiomycota* / genetics
  • Basidiomycota* / metabolism
  • Bridged Bicyclo Compounds / chemistry*
  • Genomics
  • Mixed Function Oxygenases / metabolism*
  • Prevalence
  • Slovenia
  • Substrate Specificity

Substances

  • Bridged Bicyclo Compounds
  • Mixed Function Oxygenases