Interview with Professor Janina Longtine PhD, by Claire Raison (Commissioning Editor) Janina Longtine is a professor of pathology at the Mount Sinai Hospital (New York, NY, USA) and currently serves as the President of the Association for Molecular Pathology (Bethesda, MD, USA). Prior to this, Professor Longtine was with the Brigham and Women's Hospital (Boston, MA, USA) for 30 years, working on understanding the molecular pathology of cancer and developing diagnostic procedures for cancers. In this interview article to mark 15 years of Expert Review of Molecular Diagnostics, she reflects on her experience as a molecular pathologist in US hospitals, and warns of the regulatory and reimbursement challenges that face laboratory-developed procedures today.