Predictors that Influence Election of Contralateral Prophylactic Mastectomy among Women with Ductal Carcinoma in Situ who are BRCA-Negative

Nisreen Elsayegh; Jessica Profato; Angelica M Gutierrez Barrera; Heather Lin; Henry M Kuerer; Can Ardic; Jennifer K Litton; Debasish Tripathy; Banu K Arun

doi:10.7150/jca.11710

Predictors that Influence Election of Contralateral Prophylactic Mastectomy among Women with Ductal Carcinoma in Situ who are BRCA-Negative

J Cancer. 2015 May 23;6(7):610-5. doi: 10.7150/jca.11710. eCollection 2015.

Authors

Nisreen Elsayegh¹, Jessica Profato¹, Angelica M Gutierrez Barrera², Heather Lin³, Henry M Kuerer⁴, Can Ardic², Jennifer K Litton², Debasish Tripathy², Banu K Arun⁵

Affiliations

¹ 1. Clinical Cancer Genetics, the University of Texas MD Anderson Cancer Center, Houston, TX.
² 2. Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX.
³ 3. Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX.
⁴ 4. Department of Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX.
⁵ 1. Clinical Cancer Genetics, the University of Texas MD Anderson Cancer Center, Houston, TX ; 2. Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX.

Abstract

The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing contralateral prophylactic mastectomy (CPM) among this cohort were: family history of ovarian cancer, marital status, reconstruction, mastectomy of the affected breast, and tamoxifen use.

Keywords: BRCA negative; contralateral prophylactic mastectomy.

Grants and funding

P30 CA016672/CA/NCI NIH HHS/United States