Multifunctional 3D Patternable Drug-Embedded Nanocarrier-Based Interfaces to Enhance Signal Recording and Reduce Neuron Degeneration in Neural Implantation

Adv Mater. 2015 Jul 22;27(28):4186-93. doi: 10.1002/adma.201500136. Epub 2015 Jun 13.
No abstract available

Keywords: drug delivery; hydrogel; nanocarrier(s); neural implant; neural interface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Drug Carriers / chemistry*
  • Elastic Modulus
  • Electrophysiological Phenomena
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Lactic Acid / chemistry
  • Nanoparticles / chemistry
  • Nanoparticles / toxicity
  • Nanostructures / chemistry*
  • Nanostructures / toxicity
  • Nerve Degeneration / physiopathology
  • Neurons / physiology*
  • PC12 Cells
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Rats
  • Reactive Oxygen Species / metabolism
  • Signal-To-Noise Ratio
  • Tensile Strength

Substances

  • Drug Carriers
  • Reactive Oxygen Species
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyglycolic Acid
  • Lactic Acid