Estrogenic endocrine disruptors: Molecular mechanisms of action

Ryoiti Kiyama; Yuko Wada-Kiyama

doi:10.1016/j.envint.2015.05.012

Estrogenic endocrine disruptors: Molecular mechanisms of action

Environ Int. 2015 Oct:83:11-40. doi: 10.1016/j.envint.2015.05.012. Epub 2015 Jun 11.

Authors

Ryoiti Kiyama¹, Yuko Wada-Kiyama²

Affiliations

¹ Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. Electronic address: kiyama.r@aist.go.jp.
² Department of Physiology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8602, Japan.

PMID: 26073844
DOI: 10.1016/j.envint.2015.05.012

Abstract

A comprehensive summary of more than 450 estrogenic chemicals including estrogenic endocrine disruptors is provided here to understand the complex and profound impact of estrogen action. First, estrogenic chemicals are categorized by structure as well as their applications, usage and effects. Second, estrogenic signaling is examined by the molecular mechanism based on the receptors, signaling pathways, crosstalk/bypassing and autocrine/paracrine/homeostatic networks involved in the signaling. Third, evaluation of estrogen action is discussed by focusing on the technologies and protocols of the assays for assessing estrogenicity. Understanding the molecular mechanisms of estrogen action is important to assess the action of endocrine disruptors and will be used for risk management based on pathway-based toxicity testing.

Keywords: Endocrine disruptor; Estrogen action; Molecular mechanism; Signal transduction; Techonology; Toxicity pathway.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Endocrine Disruptors / metabolism*
Endocrine Disruptors / toxicity*
Estrogens / metabolism*
Estrogens / toxicity*
Humans
Signal Transduction / drug effects*

Substances

Endocrine Disruptors
Estrogens