Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Jaeyoung Kwon; Sunita Basnet; Jin Woo Lee; Eun-Kyoung Seo; Nanzad Tsevegsuren; Bang Yeon Hwang; Dongho Lee

doi:10.1016/j.bmcl.2015.05.062

Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3314-8. doi: 10.1016/j.bmcl.2015.05.062. Epub 2015 May 30.

Authors

Jaeyoung Kwon¹, Sunita Basnet¹, Jin Woo Lee², Eun-Kyoung Seo³, Nanzad Tsevegsuren⁴, Bang Yeon Hwang², Dongho Lee⁵

Affiliations

¹ Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
² College of Pharmacy, Chungbuk National University, Cheongju 362-763, Republic of Korea.
³ College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea.
⁴ Laboratory of Functional Foods and Natural Products, Department of Chemistry, School of Arts and Sciences, National University of Mongolia, Mongolia.
⁵ Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: dongholee@korea.ac.kr.

PMID: 26073007
DOI: 10.1016/j.bmcl.2015.05.062

Abstract

Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

Keywords: Flavonostilbenes; Nitric oxide production inhibitor; Sophora alopecuroides L..

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Gene Expression Regulation / drug effects*
Humans
Inhibitory Concentration 50
Lipopolysaccharides / pharmacology
Macrophages / drug effects*
Magnetic Resonance Spectroscopy
Molecular Structure
Nitric Oxide / genetics*
Plant Bark / chemistry
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plant Roots / chemistry
Plants, Medicinal / chemistry
Sophora / chemistry*
Stilbenes / chemistry
Stilbenes / pharmacology

Substances

Anti-Inflammatory Agents
Lipopolysaccharides
Plant Extracts
Stilbenes
Nitric Oxide