An efficient and selective microwave-assisted Claisen-Schmidt reaction for the synthesis of functionalized benzalacetones

Anita Rayar; Maité Sylla-Iyarreta Veitía; Clotilde Ferroud

doi:10.1186/s40064-015-0985-8

An efficient and selective microwave-assisted Claisen-Schmidt reaction for the synthesis of functionalized benzalacetones

Springerplus. 2015 May 14:4:221. doi: 10.1186/s40064-015-0985-8. eCollection 2015.

Authors

Anita Rayar¹, Maité Sylla-Iyarreta Veitía¹, Clotilde Ferroud¹

Affiliation

¹ Laboratoire Chimie Moléculaire, génie des procédés chimiques et énergétiques (CMGPCE), EA 7341- Conservatoire National des Arts et Métiers, 2 rue Conté, 75003 Paris, France.

Abstract

A simple and direct method for the Claisen-Schmidt reaction to prepare functionalized α,β-unsaturated ketones has been developed. Microwave irradiation of aldehydes with acetone produces benzalacetones selectively without self-condensation product in very short reaction times and good yields. Graphical AbstractGraphics for use in the Table of Contents.

Keywords: Benzalacetones; Carbonyl compounds; Claisen-Schmidt reaction; Green chemistry; Microwaves-assisted synthesis.