Using water-soluble C60 fullerenes in anticancer therapy

S V Prylutska; A P Burlaka; P P Klymenko; I I Grynyuk; Yu I Prylutskyy; Ch Schütze; U Ritter

doi:10.1007/s12645-011-0020-x

Using water-soluble C₆₀ fullerenes in anticancer therapy

Cancer Nanotechnol. 2011;2(1-6):105-110. doi: 10.1007/s12645-011-0020-x. Epub 2011 Aug 19.

Authors

S V Prylutska¹, A P Burlaka², P P Klymenko³, I I Grynyuk¹, Yu I Prylutskyy¹, Ch Schütze⁴, U Ritter⁴

Affiliations

¹ Institute of Biology, Kyiv National Taras Shevchenko University, Volodymyrska Str., 64, 01601 Kyiv, Ukraine.
² R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Vasylkivska Str. 45, 03022 Kyiv, Ukraine.
³ State Institute of Gerontology of AMS of Ukraine, Vyshgorodska Str., 67, 04114 Kyiv, Ukraine.
⁴ Department of Chemistry, Technical University of Ilmenau, Weimarer Str. 25, 098693 Ilmenau, Germany.

Abstract

Growth experiments of transplanted malignant tumors in the presence of water-soluble C₆₀ fullerenes were performed on groups of mice. It was found that C₆₀ fullerenes efficiently inhibit the growth of transplanted malignant tumors. This behavior can be explained through their high antioxidant activity and the blocking of the specific cell receptors (for example, endothelial growth factor). The findings demonstrate the possibility of using C₆₀ fullerenes in anticancer therapy.

Keywords: C60 fullerenes; Histological data; Increasing of animal life; Lewis lung carcinoma; Metastasis inhibition index; Mice line C57Bl/6J; Survival of animals; Tumor growth inhibition.