Abstract
A mild catalyst system for the synthesis of chiral amino alcohols via asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones has been developed by using a chiral Ru-TsDPEN complex as the catalyst in DMF/MeOH at 40 °C. The reaction exhibits high reaction activity and excellent enantioselectivity where up to 96% yield and 99% ee of the product were obtained.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemical synthesis
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Alcohols / chemistry
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Ethylenediamines / chemistry
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Hydrogenation
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Ketones / chemistry*
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Organometallic Compounds / chemistry
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Phthalimides / chemistry*
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Solvents
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Stereoisomerism
Substances
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Alcohols
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Ethylenediamines
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Ketones
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Organometallic Compounds
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Phthalimides
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Solvents
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ruthenium-(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine
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phthalimide