Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer

Cancer Invest. 2015;33(8):354-60. doi: 10.3109/07357907.2015.1047507. Epub 2015 Jun 12.

Abstract

Although peritoneal carcinomatosis (PC) displays advanced stage in colorectal cancer (CRC), most patients present without distant metastases. To analyze the expression of cancer stem cell markers immunohistochemistry for CD133, CD44 and β-catenin was applied to CRC with exclusive PC, exclusive hepatic metastasis and CRC with combined spread. Expression of cancer stem cell markers correlated with hematogeneous metastases to the liver and was absent in patients with exclusive PC. Thus, expression of cancer stem cell markers correlates with different patterns of metastatic spread in CRC. These data indicate that CRC with exclusive PC lack stem cell features needed for distant dissemination.

Keywords: CD133; CD44; Colorectal cancer; Liver metastasis; Peritoneal carcinomatosis; β-catenin.

Publication types

  • Clinical Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AC133 Antigen
  • Aged
  • Antigens, CD / analysis
  • Biomarkers, Tumor / analysis*
  • Case-Control Studies
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Colorectal Neoplasms / surgery
  • Female
  • Glycoproteins / analysis
  • Humans
  • Hyaluronan Receptors / analysis
  • Immunohistochemistry
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary*
  • Male
  • Middle Aged
  • Neoplastic Stem Cells / metabolism*
  • Peptides / analysis
  • Peritoneal Neoplasms / pathology
  • Peritoneal Neoplasms / secondary*
  • beta Catenin / analysis

Substances

  • AC133 Antigen
  • Antigens, CD
  • Biomarkers, Tumor
  • CD44 protein, human
  • CTNNB1 protein, human
  • Glycoproteins
  • Hyaluronan Receptors
  • PROM1 protein, human
  • Peptides
  • beta Catenin