1 Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan ; Department of Computer Science and Information Engineering, Asia University, Taichung 41354, Taiwan ; Department of Science Education, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, China.
2 Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto 606-8501, Japan.
3 Department of Computer Science, Wayne State University, Detroit, MI 48202, USA.
4 Department of Computer Science, University of Bristol, Bristol BS8 1UB, UK.
5 Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung 20224, Taiwan ; Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan.