Effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide to rat spleen lymphoid cells

J Jimenez; R Goberna; J C Mesa; M F Morales; J R Calvo

doi:10.1016/0306-3623(89)90103-1

Effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide to rat spleen lymphoid cells

Gen Pharmacol. 1989;20(5):659-62. doi: 10.1016/0306-3623(89)90103-1.

Authors

J Jimenez¹, R Goberna, J C Mesa, M F Morales, J R Calvo

Affiliation

¹ Departamento de Bioquimica Médica y Biología Molecular, Facultad de Medicina, Adva, Sánchez, Pizjuán, Sevilla, Spain.

PMID: 2606334
DOI: 10.1016/0306-3623(89)90103-1

Abstract

1. The effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide (VIP) to rat spleen lymphoid cells was investigated. 2. The intake chronic of ethanol elicited an increase in specific VIP binding. 3. This increase was due to an increase in binding capacity of both the high and the low affinity binding sites. 4. There was a decrease in the affinities of both classes of VIP binding sites.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcoholism / metabolism
Animals
Ethanol / pharmacology*
In Vitro Techniques
Iodine Radioisotopes
Kinetics
Lymphoid Tissue / cytology
Lymphoid Tissue / metabolism*
Rats
Rats, Inbred Strains
Spleen / cytology
Spleen / drug effects
Spleen / metabolism*
Vasoactive Intestinal Peptide / metabolism*

Substances

Iodine Radioisotopes
Vasoactive Intestinal Peptide
Ethanol