Anti-inflammatory diterpene dimers from the root barks of Aphanamixis grandifolia

Org Biomol Chem. 2015 Jul 21;13(27):7452-8. doi: 10.1039/c5ob00674k.

Abstract

A total of 14 new diterpene dimers, aphanamenes C-P ()1-14, with four known homologous compounds were isolated from the root barks of Aphanamixis grandifolia Bl. The structures of these compounds were elucidated by spectroscopic analyses, and their absolute configurations were determined using the CD exciton chirality method. In addition, all the compounds exhibited significant inhibition of lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC50 values between 7.75 and 38.23 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemical synthesis
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Biological Assay
  • Biosynthetic Pathways / drug effects
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Cell Death / drug effects
  • Circular Dichroism
  • Dimerization*
  • Diterpenes / chemical synthesis
  • Diterpenes / chemistry
  • Diterpenes / pharmacology*
  • Meliaceae / chemistry*
  • Mice
  • Plant Bark / chemistry*
  • Plant Roots / chemistry*
  • Proton Magnetic Resonance Spectroscopy
  • RAW 264.7 Cells
  • Stereoisomerism

Substances

  • Anti-Inflammatory Agents
  • Diterpenes