Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69

Zhuang Ding; Lianqing Zhang; Juan Fu; Qian Che; Dehai Li; Qianqun Gu; Tianjiao Zhu

doi:10.1038/ja.2015.64

Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69

J Antibiot (Tokyo). 2015 Dec;68(12):748-51. doi: 10.1038/ja.2015.64. Epub 2015 Jun 10.

Authors

Zhuang Ding¹, Lianqing Zhang¹, Juan Fu¹, Qian Che¹, Dehai Li¹, Qianqun Gu¹, Tianjiao Zhu¹

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

PMID: 26058567
DOI: 10.1038/ja.2015.64

Abstract

Two new meroterpenes, phenylpyropenes E (1) and F (2), together with seven known phenylpyropenes (3-5) and pyripyropenes (6-9) were isolated from the marine-derived fungus Penicillium concentricum ZLQ-69. Their structures including the absolute configurations were elucidated using a combination of spectroscopic methods and electronic circular dichroism calculation. Bioactivity evaluation showed that compounds 1 and 4 were cytotoxic to the MGC-803 cell line with IC50 values of 19.1 and 13.6 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Circular Dichroism
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / isolation & purification
Heterocyclic Compounds, 4 or More Rings / pharmacology
Humans
Inhibitory Concentration 50
Penicillium / chemistry*
Spectrum Analysis
Stomach Neoplasms / drug therapy*
Stomach Neoplasms / pathology
Terpenes / chemistry
Terpenes / isolation & purification
Terpenes / pharmacology*

Substances

Antineoplastic Agents
Heterocyclic Compounds, 4 or More Rings
Terpenes
phenylpyropene E