Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults

Jian Hou; Chuanyao Liu; Ping Yao; Weihong Chen; Meian He; Youjie Wang; Yuan Liang; Xiaoping Miao; Sheng Wei; Tian Xu; Weimin Fang; Jiang Zhu; Xiulou Li; Frank B Hu; Tangchun Wu; Handong Yang; Jing Yuan

doi:10.1371/journal.pone.0129677

Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults

PLoS One. 2015 Jun 9;10(6):e0129677. doi: 10.1371/journal.pone.0129677. eCollection 2015.

Authors

Jian Hou¹, Chuanyao Liu¹, Ping Yao², Weihong Chen¹, Meian He¹, Youjie Wang³, Yuan Liang⁴, Xiaoping Miao⁵, Sheng Wei⁵, Tian Xu¹, Weimin Fang⁶, Jiang Zhu⁷, Xiulou Li⁸, Frank B Hu⁹, Tangchun Wu¹, Handong Yang¹⁰, Jing Yuan¹

Affiliations

¹ Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China.
² MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China.
³ MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China; Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China.
⁴ MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China; Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China.
⁶ Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R.China.
⁷ Physical Examination Center, Dongfeng Central Hospital, Dongfeng Motor Corporation, Shiyan, Hubei, 442008, Hubei, P.R.China.
⁸ Department of Clinic Teaching and Science, Dongfeng Central Hospital, Dongfeng Motor Corporation, Shiyan, Hubei, 442008, Hubei, P.R.China.
⁹ Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, 02115, Massachusetts, United States of America.
¹⁰ Department of Cardiology, Dongfeng Central Hospital, Dongfeng Motor Corporation, Shiyan 442008, Hubei, China, P.R.China.

Abstract

Hypoxia is a prominent characteristic of inflammatory tissue lesions. It can affect platelet function. While mean platelet volume (MPV) and platelet distribution width (PDW) are sample platelet indices, they may reflect subcinical platelet activation. To investigated associations between adiposity indices and platelet indices, 17327 eligible individuals (7677 males and 9650 females) from the Dongfeng-Tongji Cohort Study (DFTJ-Cohort Study, n=27009) were included in this study, except for 9682 individuals with missing data on demographical, lifestyle, physical indicators and diseases relative to PDW and MPV. Associations between adiposity indices including waist circumstance (WC), waist-to-height ratio (WHtR), body mass index (BMI), and MPV or PDW in the participants were analyzed using multiple logistic regressions. There were significantly negative associations between abnormal PDW and WC or WHtR for both sexes (ptrend<0.001 for all), as well as abnormal MPV and WC or WHtR among female participants (ptrend<0.05 for all). In the highest BMI groups, only females with low MPV or PDW were at greater risk for having low MPV (OR=1.33, 95% CI=1.10, 1.62 ptrend<0.001) or PDW (OR=1.34, 95% CI=1.14, 1.58, ptrend<0.001) than those who had low MPV or PDW in the corresponding lowest BMI group. The change of PDW seems more sensitive than MPV to oxidative stress and hypoxia. Associations between reduced PDW and MPV values and WC, WHtR and BMI values in Chinese female adults may help us to further investigate early changes in human body.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adiposity*
Aged
Asian People*
Blood Platelets / physiology*
Body Mass Index
China
Demography
Female
Humans
Male
Mean Platelet Volume*
Middle Aged
Waist-Height Ratio

Grants and funding

This work was supported by research funds from the National Key Basic Research and Development Program (2011CB503800, TC, Wu and 2011CB5038004, WH, Chen); the 111 Project (No. B12004, TC, Wu); the Program for Changjiang Scholars (TC, Wu); Innovative Research Team in University of Ministry of Education of China (NO. IRT1246), China Medical Board (No. 12-113, TC, Wu). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Dongfeng Motor Corporation only provided support in the form of salaries for authors [J Zhu, XL Li, and HD Yang], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the author contributions section.