Chemistry for oncotheranostic gold nanoparticles

Anne Juliette Trouiller; Seydou Hebié; Fatima El Bahhaj; Teko W Napporn; Philippe Bertrand

doi:10.1016/j.ejmech.2015.05.024

Chemistry for oncotheranostic gold nanoparticles

Eur J Med Chem. 2015 Jun 24:99:92-112. doi: 10.1016/j.ejmech.2015.05.024. Epub 2015 May 20.

Authors

Anne Juliette Trouiller¹, Seydou Hebié², Fatima El Bahhaj¹, Teko W Napporn², Philippe Bertrand³

Affiliations

¹ University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et des Matériaux de Poitiers, Equipe Synthèse Organique, 4 rue Michel Brunet, B28, 86073 Poitiers, France.
² University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et des Matériaux de Poitiers, Equipe SAMCat, 4 rue Michel Brunet, B27, 86073 Poitiers, France.
³ University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et des Matériaux de Poitiers, Equipe Synthèse Organique, 4 rue Michel Brunet, B28, 86073 Poitiers, France. Electronic address: Philippe.bertrand@univ-poitiers.fr.

PMID: 26057706
DOI: 10.1016/j.ejmech.2015.05.024

Abstract

This review presents in a comprehensive ways the chemical methods used to functionalize gold nanoparticles with focus on anti-cancer applications. The review covers the parameters required for the synthesis gold nanoparticles with defined shapes and sizes, method for targeted delivery in tumours, and selected examples of anti-cancers compounds delivered with gold nanoparticles. A short survey of bioassays for oncology based on gold nanoparticles is also presented.

Keywords: Cancer; Diagnostic; Gold; Nanoparticles; Therapy.

Publication types

Review

MeSH terms

Gold / chemistry*
Gold / pharmacokinetics
Gold / therapeutic use*
Humans
Metal Nanoparticles*
Neoplasms / diagnosis*
Neoplasms / drug therapy*
Theranostic Nanomedicine / methods*

Substances

Gold