Abstract
We identified New Delhi metallo-β-lactamase (NDM-1)-producing Citrobacter freundii GB032, Escherichia coli GB102, and Acinetobacter baumannii GB661 in urine and stool samples from a single patient in China. Plasmid profiling and Southern blotting indicated that blaNDM-1 from GB032 and that from GB102 were likely located on the same plasmid, while blaNDM-1 from GB661 was located on a very large (>400-kb) plasmid. This case underscores the broad host range of blaNDM-1 and its potential to spread between members of the family Enterobacteriaceae and A. baumannii.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / drug therapy
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / isolation & purification
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Anti-Bacterial Agents / therapeutic use
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China
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Citrobacter freundii / drug effects*
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Citrobacter freundii / genetics
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Citrobacter freundii / isolation & purification
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Drug Resistance, Multiple, Bacterial / genetics*
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Enterobacteriaceae Infections / drug therapy
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Feces / microbiology
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Molecular Sequence Data
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Multilocus Sequence Typing
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Plasmids / genetics
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Plasmids / isolation & purification
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Urine / microbiology
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beta-Lactamases / biosynthesis
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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beta-Lactamases
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beta-lactamase NDM-1