Breviscapine Injection Improves the Therapeutic Effect of Western Medicine on Angina Pectoris Patients

Chuan Wang; Yafeng Li; Shoucui Gao; Daxin Cheng; Sihai Zhao; Enqi Liu

doi:10.1371/journal.pone.0129969

Breviscapine Injection Improves the Therapeutic Effect of Western Medicine on Angina Pectoris Patients

PLoS One. 2015 Jun 8;10(6):e0129969. doi: 10.1371/journal.pone.0129969. eCollection 2015.

Authors

Chuan Wang¹, Yafeng Li², Shoucui Gao², Daxin Cheng³, Sihai Zhao², Enqi Liu²

Affiliations

¹ Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University Cardiovascular Research Center, Shaanxi, China; Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
² Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University Cardiovascular Research Center, Shaanxi, China.
³ Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University Cardiovascular Research Center, Shaanxi, China; The Third Affiliated Hospital of the School of Medicine, Xi'an Jiaotong University, Shaanxi, China.

Abstract

To evaluate the beneficial and adverse effects of breviscapine injection in combination with Western medicine on the treatment of patients with angina pectoris. The Cochrane Central Register of Controlled Trials, Medline, Science Citation Index, EMBASE, the China National Knowledge Infrastructure, the Wanfang Database, the Chongqing VIP Information Database and the China Biomedical Database were searched to identify randomized clinical trials (RCTs) that evaluated the effects of Western medicine compared to breviscapine injection plus Western medicine on angina pectoris patients. The included studies were analyzed using RevMan 5.1.0 software. The literature search yielded 460 studies, wherein 16 studies matched the selection criteria. The results showed that combined therapy using Breviscapine plus Western medicine was superior to Western medicine alone for improving angina pectoris symptoms (OR=3.77, 95% Cl: 2.76~5.15) and also resulted in increased electrocardiogram (ECG) improvement (OR=2.77, 95% Cl: 2.16~3.53). The current evidence suggests that Breviscapine plus Western medicine achieved a superior therapeutic effect compared to Western medicine alone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angina Pectoris / diagnostic imaging
Angina Pectoris / drug therapy*
Flavonoids / adverse effects
Flavonoids / therapeutic use*
Humans
Injections
Publication Bias
Randomized Controlled Trials as Topic
Ultrasonography

Substances

Flavonoids
breviscapine

Grants and funding

This work was supported in part by the National Natural Science Foundation of China (No. 81370379), the Fundamental Research Funds for the Central Universities and the Natural Science Foundation of Shaanxi Province (2012KJXX-07). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.