Animal models of glucocorticoid-induced glaucoma

Exp Eye Res. 2015 Dec:141:15-22. doi: 10.1016/j.exer.2015.06.002. Epub 2015 Jun 4.

Abstract

Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.

Keywords: Glaucoma; Glucocorticoid; Intraocular pressure; Ocular hypertension; Steroid glaucoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Glaucoma / chemically induced*
  • Glaucoma / physiopathology
  • Glucocorticoids / toxicity*
  • Intraocular Pressure / drug effects*

Substances

  • Glucocorticoids