Prasugrel Hydrochloride

Mahmoud M H Al Omari; Nidal A Qinna; Iyad S Rashid; Khaldoun A Al-Sou'od; Adnan A Badwan

doi:10.1016/bs.podrm.2015.01.002

Prasugrel Hydrochloride

Profiles Drug Subst Excip Relat Methodol. 2015:40:195-320. doi: 10.1016/bs.podrm.2015.01.002. Epub 2015 Mar 23.

Authors

Mahmoud M H Al Omari¹, Nidal A Qinna², Iyad S Rashid³, Khaldoun A Al-Sou'od⁴, Adnan A Badwan³

Affiliations

¹ The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan. Electronic address: momari@jpm.com.jo.
² Faculty of Pharmacy and Medical Sciences, Petra University, Amman, Jordan.
³ The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan.
⁴ Department of Chemistry, Al al-Bayt University, Mafraq, Jordan.

PMID: 26051687
DOI: 10.1016/bs.podrm.2015.01.002

Abstract

A comprehensive profile of prasugrel HCl is reported herein with 158 references. A full description including nomenclature, formulae, elemental analysis, and appearance is included. Methods of preparation for prasugrel HCl, its intermediates, and derivatives are fully discussed. In addition, the physical properties, analytical methods, stability, uses and applications, and pharmacology of prasugrel HCl are also discussed.

Keywords: ADME; Analysis; Antiplatelet agent; Comprehensive profile; Prasugrel; Preparation; Stability; Thienopyridine.

Publication types

Review

MeSH terms

Animals
Chemistry, Pharmaceutical
Drug Stability
Humans
Molecular Structure
Piperazines / chemistry*
Piperazines / pharmacokinetics
Piperazines / pharmacology
Platelet Aggregation Inhibitors / chemistry*
Platelet Aggregation Inhibitors / pharmacokinetics
Platelet Aggregation Inhibitors / pharmacology
Prasugrel Hydrochloride
Purinergic P2Y Receptor Antagonists / chemistry*
Purinergic P2Y Receptor Antagonists / pharmacokinetics
Purinergic P2Y Receptor Antagonists / pharmacology
Technology, Pharmaceutical / methods
Thiophenes / chemistry*
Thiophenes / pharmacokinetics
Thiophenes / pharmacology

Substances