Congenital vomer agenesis is a very rare condition. Usually, it is discovered incidentally. Nasal and otologic diseases accompany the cases. In this article, we report two cases of isolated congenital vomer agenesis who were admitted to our clinic with complaint of nasal obstruction. On endoscopic examination, deviated septum and inferior turbinate hypertrophy were observed in both patients. One patient was performed septoplasty, inferior turbinate radiofrequency, and functional endoscopic sinus surgery. Other patient was advised follow-up since the patient did not consent to operation.