Functional polymorphism rs710218 in the gene coding GLUT1 protein is associated with in-stent restenosis

Biomark Med. 2015;9(8):743-50. doi: 10.2217/bmm.15.36. Epub 2015 Jun 8.

Abstract

Aim: To analyze the association between in-stent restenosis (ISR) and polymorphisms in genes coding IGF-1, IGFBP3, ITGB3 and GLUT1, which play an important role in the smooth muscle cell proliferation and extracellular matrix synthesis - the main components of neointima.

Materials & methods: We analyzed 265 patients who underwent bare metal stent implantation.

Results: The differences in the occurrence of ISR between genotypes of the analyzed polymorphisms in the IGF-1, IGFBP3 and ITGB3 were not statistically significant. The T/T genotype of the rs710218 polymorphism in the GLUT1 (SLC2A1) gene was more common in the ISR group compared with non-ISR patients (81.1 vs 64.8%; p = 0.02). In a multivariable model the A/A and A/T genotype remained correlated with lower occurrence of ISR (odds ratio: 0.45; 95% CI: 0.21-0.97; p = 0.03).

Conclusion: The rs710218 polymorphism in the gene coding GLUT1 protein is a novel risk factor for ISR.

Keywords: GLUT1; IGF-1; IGFBP3; ITGB3; SLC2A1; glucose transporter; growth factors; polymorphism; restenosis; stent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Coronary Restenosis / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Glucose Transporter Type 1 / genetics*
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / genetics
  • Insulin-Like Growth Factor I / genetics
  • Integrin beta3 / genetics
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Polymorphism, Single Nucleotide*
  • Stents*

Substances

  • Glucose Transporter Type 1
  • IGFBP3 protein, human
  • ITGB3 protein, human
  • Insulin-Like Growth Factor Binding Protein 3
  • Integrin beta3
  • SLC2A1 protein, human
  • Insulin-Like Growth Factor I