[Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity]

M P Davydova; I V Sorokina; T G Tolstikova; V I Mamatyuk; D S Fadeev; S F Vasilevsky

doi:10.1134/s1068162015010033

[Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity]

Bioorg Khim. 2015 Jan-Feb;41(1):82-9. doi: 10.1134/s1068162015010033.

[Article in Russian]

Authors

M P Davydova, I V Sorokina, T G Tolstikova, V I Mamatyuk, D S Fadeev, S F Vasilevsky

PMID: 26050475
DOI: 10.1134/s1068162015010033

Abstract

New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal* / chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal* / chemistry
Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
Antineoplastic Agents, Phytogenic / chemical synthesis
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Male
Mice
Stilbenes* / chemical synthesis
Stilbenes* / chemistry
Stilbenes* / pharmacology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents, Phytogenic
Stilbenes
fosbretabulin