Kicking Out Pathogens in Exosomes

Oksana A Sergeeva; F Gisou van der Goot

doi:10.1016/j.cell.2015.05.040

Kicking Out Pathogens in Exosomes

Cell. 2015 Jun 4;161(6):1241-2. doi: 10.1016/j.cell.2015.05.040.

Authors

Oksana A Sergeeva¹, F Gisou van der Goot²

Affiliations

¹ Global Health Institute, École Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland.
² Global Health Institute, École Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland. Electronic address: gisou.vandergoot@epfl.ch.

PMID: 26046431
DOI: 10.1016/j.cell.2015.05.040

Abstract

Host-pathogen interactions involve a series of attacks and counter-attacks. Miao et al. show that, although some invading bacteria can take shelter in lysosomes by neutralizing their pH, this respite is temporary, as host cells can expel them in exosomes.

Publication types

Comment

MeSH terms

Animals
Escherichia coli Infections / immunology*
Lysosomes / microbiology*
TRPC Cation Channels / metabolism*
Transient Receptor Potential Channels / metabolism*
Urinary Tract Infections / immunology*
Uropathogenic Escherichia coli / physiology*

Substances

TRPC Cation Channels
Transient Receptor Potential Channels