Effect of transforming growth factor-β1 869C/T polymorphism and radiation pneumonitis

Int J Clin Exp Pathol. 2015 Mar 1;8(3):2835-9. eCollection 2015.

Abstract

Background: The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted.

Methods: Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models.

Results: There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007).

Conclusion: This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.

Keywords: Radiation pneumonitis; meta-analysis; polymorphism; transforming growth factor.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Genetic Predisposition to Disease
  • Humans
  • Odds Ratio
  • Phenotype
  • Polymorphism, Genetic*
  • Radiation Pneumonitis / diagnosis
  • Radiation Pneumonitis / genetics*
  • Risk Assessment
  • Risk Factors
  • Transforming Growth Factor beta1 / genetics*

Substances

  • TGFB1 protein, human
  • Transforming Growth Factor beta1