Peripheral blood stem cell mobilization from healthy donors

Melda Comert Ozkan; Fahri Sahin; Guray Saydam

doi:10.1016/j.transci.2015.05.008

Peripheral blood stem cell mobilization from healthy donors

Transfus Apher Sci. 2015 Aug;53(1):13-6. doi: 10.1016/j.transci.2015.05.008. Epub 2015 May 19.

Authors

Melda Comert Ozkan¹, Fahri Sahin¹, Guray Saydam²

Affiliations

¹ Department of Hematology, Ege University Medical School, İzmir, Turkey.
² Department of Hematology, Ege University Medical School, İzmir, Turkey. Electronic address: guray.saydam@gmail.com.

PMID: 26043813
DOI: 10.1016/j.transci.2015.05.008

Abstract

Most frequently used graft of hematopoietic stem cells (HSCs) for allogeneic transplantation is peripheral blood stem cells (PBSCs) that are collected after mobilization with frequently granulocyte colony-stimulating factor (G-CSF). Administration of the optimal dose of G-CSF while preserving the donor health is one of the most important points for sufficient PBSC mobilization and harvest. We hereby tried to summarize characteristic features, potential side effects and main topics in peripheral blood stem cell mobilization from healthy donors.

Keywords: Granulocyte-colony stimulating factor; Healthy donors; Peripheral stem cell mobilization.

Publication types

Review

MeSH terms

Granulocyte Colony-Stimulating Factor / therapeutic use*
Hematopoietic Stem Cell Mobilization / methods*
Hematopoietic Stem Cells*
Humans
Tissue Donors*

Substances

Granulocyte Colony-Stimulating Factor