Newborn craniofacial malformations: orofacial clefting and craniosynostosis

J Austin Hamm; Nathaniel H Robin

doi:10.1016/j.clp.2015.02.005

Newborn craniofacial malformations: orofacial clefting and craniosynostosis

Clin Perinatol. 2015 Jun;42(2):321-36, viii. doi: 10.1016/j.clp.2015.02.005. Epub 2015 Apr 15.

Authors

J Austin Hamm¹, Nathaniel H Robin²

Affiliations

¹ Department of Genetics, The University of Alabama at Birmingham, 213 Kaul Human Genetics Building, 720 20th Street South, Birmingham, AL 35294, USA.
² Department of Genetics, The University of Alabama at Birmingham, 213 Kaul Human Genetics Building, 720 20th Street South, Birmingham, AL 35294, USA; Department of Pediatrics, The University of Alabama at Birmingham, 1600 7th Avenue South, CPPI 310, Birmingham, AL 35233, USA; Division of Otolaryngology, Department of Surgery, The University of Alabama at Birmingham, 563 Boshell Building, Birmingham, AL 35294, USA. Electronic address: nrobin@uab.edu.

PMID: 26042907
DOI: 10.1016/j.clp.2015.02.005

Abstract

Craniofacial malformations are among the most common birth defects. Although most cases of orofacial clefting and craniosynostosis are isolated and sporadic, these abnormalities are associated with a wide range of genetic syndromes, and making the appropriate diagnosis can guide management and counseling. Patients with craniofacial malformation are best cared for in a multidisciplinary clinic that can coordinate the care delivered by a diverse team of providers.

Keywords: Craniofacial malformations; Craniosynostosis; Genetic syndromes; Multidisciplinary clinics; Orofacial clefting.

Publication types

Review

MeSH terms

Cleft Palate / diagnosis
Cleft Palate / epidemiology
Cleft Palate / genetics
Craniofacial Abnormalities* / diagnosis
Craniofacial Abnormalities* / epidemiology
Craniofacial Abnormalities* / genetics
Craniosynostoses / diagnosis
Craniosynostoses / epidemiology
Craniosynostoses / genetics
Genetic Testing
Global Health
Humans
Infant, Newborn
Morbidity