[Physical activity in patients with symptoms of metabolic syndrome reduces the concentration of plasma antioxidant vitamins - protective effect of vitamin C]

Małgorzata Godala; Izabela Materek-Kuśmierkiewicz; Dariusz Moczulski; Maciej Rutkowski; Franciszek Szatko; Ewelina Gaszyńska; Sławomir Tokarski; Jan Kowalski

[Physical activity in patients with symptoms of metabolic syndrome reduces the concentration of plasma antioxidant vitamins - protective effect of vitamin C]

Pol Merkur Lekarski. 2015 May;38(227):258-62.

[Article in Polish]

Authors

Małgorzata Godala¹, Izabela Materek-Kuśmierkiewicz², Dariusz Moczulski², Maciej Rutkowski³, Franciszek Szatko⁴, Ewelina Gaszyńska⁴, Sławomir Tokarski⁵, Jan Kowalski⁶

Affiliations

¹ Medical University of Lodz, Poland: Department of Hygiene of Nutrition and Epidemiology.
² Medical University of Lodz, Poland: Department of Internal Diseases and Nephrodiabetology.
³ Medical University of Lodz, Poland: Department of Military Toxicology and Radiological Protection.
⁴ Medical University of Lodz, Poland: Department of Hygiene and Health Promotion.
⁵ Faculty of Medicine, University of Rzeszow, Poland; Department of Pulmonology and Allergology, Subcarpatian Centre of Pulmonary Diseases in Rzeszow, Poland.
⁶ Medical University of Lodz, Poland: Department of Internal and Infectious Diseases;

PMID: 26039019

Abstract

Patients with cardiovascular diseases, including those with the symptoms of metabolic syndrome (MS), are recommended regular exercise but many studies indicate its role in the production of reactive oxygen species. Vitamin C supplementation may enhance the antioxidant barrier in MS patients.

Aim: The aim of the study was to assess the impact of regular physical activity (PA)and vitamin C supplementation on plasma vitamin A, C and E levels in patients with MS.

Materials and methods: The study included 62 patients with MS according to International Diabetes Federation criteria, 32 men and 30 women, aged 38-57 years (mean age 51,24 ± 5,29 years). The patients were divided in two groups: group I (MS+PA) - 31 patients with recommended regular physical activity; group II ( MS+PA+C) - 31 patients with recommended regular physical activity and vitamin C supplementation per os. The control group consisted of 23 healthy individuals without MS, 17 men and 6 women, aged 49-56 years (mean age 53,21 ± 3,6 years), who were not recommended any vitamin supplementation nor physical activity. Plasma vitamin A, C and E levels were estimated in MS patients with spectrophotometry using T60V spectrophotometer (PG Instruments) before and after regular exercise with and without vitamin C supplementation. In the control group plasma levels of antioxidant vitamins were assessed only once.

Results: The plasma vitamin A, C and E levels were significantly lower (p<0,05) in MS patients than in the control group. After 6 weeks of regular physical activity a significant fall in plasma levels of antioxidant vitamins was observed in MS patients. In the group of patients with regular physical activity and vitamin C supplementation there was detected a significant rise in the level of all the tested vitamins close to the levels in control group.

Conclusions: Regular physical activity enhances the decrease in plasma antioxidant vitamin level in patients with MS. Vitamin C supplementation conducted in parallel with regular physical activity normalize plasma vitamin A, C and E levels in these patients.

Keywords: antioxidative vitamins; avitamin C supplementation; metabolic syndrome; oxidative stress; physical activity.

Publication types

Controlled Clinical Trial

MeSH terms

Adult
Antioxidants / physiology
Ascorbic Acid / blood*
Ascorbic Acid / therapeutic use*
Dietary Supplements
Exercise / physiology*
Female
Humans
Male
Metabolic Syndrome / physiopathology*
Metabolic Syndrome / therapy*
Middle Aged
Vitamin A / blood*
Vitamin E / blood*

Substances

Antioxidants
Vitamin A
Vitamin E
Ascorbic Acid