Abstract
This comparative review highlights animal models of adrenocortical neoplasia useful either for mechanistic studies or translational research. Three model species-mouse, ferret, and dog-are detailed. The relevance of each of these models to spontaneous and inherited adrenocortical tumors in humans is discussed.
Keywords:
Adrenal cortex; Cushing syndrome; Dog; Endocrine tumor; Ferret; Gonadectomy; Mouse.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adrenal Cortex Neoplasms / drug therapy
-
Adrenal Cortex Neoplasms / genetics*
-
Adrenal Cortex Neoplasms / metabolism
-
Adrenocortical Adenoma / drug therapy
-
Adrenocortical Adenoma / genetics*
-
Adrenocortical Adenoma / metabolism
-
Animals
-
Carcinogenesis / genetics*
-
Carcinogenesis / metabolism
-
Cushing Syndrome / drug therapy
-
Cushing Syndrome / genetics
-
Cushing Syndrome / metabolism
-
Disease Models, Animal*
-
Dogs
-
Drug Screening Assays, Antitumor
-
Ferrets
-
Mice
-
Neoplasm Transplantation
-
Neoplasms, Experimental