Animal models of adrenocortical tumorigenesis

Endocrinol Metab Clin North Am. 2015 Jun;44(2):297-310. doi: 10.1016/j.ecl.2015.02.003.

Abstract

This comparative review highlights animal models of adrenocortical neoplasia useful either for mechanistic studies or translational research. Three model species-mouse, ferret, and dog-are detailed. The relevance of each of these models to spontaneous and inherited adrenocortical tumors in humans is discussed.

Keywords: Adrenal cortex; Cushing syndrome; Dog; Endocrine tumor; Ferret; Gonadectomy; Mouse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Neoplasms / drug therapy
  • Adrenal Cortex Neoplasms / genetics*
  • Adrenal Cortex Neoplasms / metabolism
  • Adrenocortical Adenoma / drug therapy
  • Adrenocortical Adenoma / genetics*
  • Adrenocortical Adenoma / metabolism
  • Animals
  • Carcinogenesis / genetics*
  • Carcinogenesis / metabolism
  • Cushing Syndrome / drug therapy
  • Cushing Syndrome / genetics
  • Cushing Syndrome / metabolism
  • Disease Models, Animal*
  • Dogs
  • Drug Screening Assays, Antitumor
  • Ferrets
  • Mice
  • Neoplasm Transplantation
  • Neoplasms, Experimental