Novel vaccine concept based on back-boost effect in viral infection

Heinz Kohler

doi:10.1016/j.vaccine.2015.05.035

Novel vaccine concept based on back-boost effect in viral infection

Vaccine. 2015 Jun 26;33(29):3274-5. doi: 10.1016/j.vaccine.2015.05.035. Epub 2015 May 30.

Author

Heinz Kohler¹

Affiliation

¹ Univ. of Kentucky, Microbiology/Immunology, 800 Rose Street, Lexington, KY 40536, United States. Electronic address: hkohl00@uky.edu.

PMID: 26032350
DOI: 10.1016/j.vaccine.2015.05.035

Abstract

A novel vaccine concept is discussed based on recent evidence of a "back-boost" effect in Influenza infection. The initial immune response to the infection is imprinted through an immune memory pathway. The immune memory in the back-boost mechanism could be used in reversed order as a "forward-boost" in the proposed vaccine concept.

Keywords: Antibody; Deceptive imprinting; HIV-1; Influenza; Vaccine; Viral infection.

MeSH terms

Communicable Diseases / immunology*
Humans
Immunization, Secondary*
Immunologic Memory*
Vaccination / methods
Vaccines / administration & dosage*
Vaccines / immunology*

Substances

Vaccines